By Ion Mandoiu,Alexander Zelikovsky
Introduces readers to middle algorithmic thoughts for next-generation sequencing (NGS) facts research and discusses a variety of computational recommendations and applications
This publication offers an in-depth survey of a few of the hot advancements in NGS and discusses mathematical and computational demanding situations in numerous software parts of NGS applied sciences. The 18 chapters featured during this publication were authored by way of bioinformatics specialists and signify the most recent paintings in top labs actively contributing to the fast-growing box of NGS. The publication is split into 4 parts:
Part I makes a speciality of computing and experimental infrastructure for NGS research, together with chapters on cloud computing, modular pipelines for metabolic pathway reconstruction, pooling recommendations for large viral sequencing, and high-fidelity sequencing protocols.
Part II concentrates on research of DNA sequencing information, masking the vintage scaffolding challenge, detection of genomic editions, together with insertions and deletions, and research of DNA methylation sequencing data.
Part III is dedicated to research of RNA-seq facts. This half discusses algorithms and compares software program instruments for transcriptome meeting besides tools for detection of different splicing and instruments for transcriptome quantification and differential expression analysis.
Part IV explores computational instruments for NGS purposes in microbiomics, together with a dialogue on blunders correction of NGS reads from viral populations, tools for viral quasispecies reconstruction, and a survey of cutting-edge tools and destiny traits in microbiome analysis.
Computational equipment for subsequent new release Sequencing facts Analysis:
- Reviews computational thoughts equivalent to new combinatorial optimization tools, info constructions, excessive functionality computing, desktop studying, and inference algorithms
- Discusses the mathematical and computational demanding situations in NGS technologies
- Covers NGS mistakes correction, de novo genome transcriptome meeting, version detection from NGS reads, and more
This textual content is a reference for biomedical execs attracted to increasing their wisdom of computational options for NGS facts research. The e-book can be precious for graduate and post-graduate scholars in bioinformatics.
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Computational Methods for Next Generation Sequencing Data Analysis (Wiley Series in Bioinformatics) by Ion Mandoiu,Alexander Zelikovsky